2-Phenylethanol → Methanesulfonic acid, 2-phenylethyl ester

HRID 1773860노트

반응식

HRID 1773860 반응식
[C:1]1([CH2:7][CH2:8][OH:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CCN(CC)CC.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>C(Cl)Cl>[CH2:8]([O:9][S:18]([CH3:17])(=[O:20])=[O:19])[CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 60542-PhenylethanolHCID 8471TriethylamineHCID 31297Methanesulfonyl chloride

생성물 1

HCID 146679Methanesulfonic acid, 2-phenylethyl ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

To a solution of 2-phenylethanol (24.4 g, 0.2 mole) in CH2Cl2 (200 mL) is added NEt3 (30.7 mL, 0.22 mole). The reaction mixture is cooled to 0° C. and methanesulfonyl chloride (16.3 mL, 0.21 mole) is added dropwise. The reaction mixture is allowed to reach room temperature and is stirred at room temperature overnight. Solvent is removed under reduced pressure. Water is added and the aqueous phase is extracted three times with Et2O. The organic phase is washed with water, brine, dried over magnesium sulphate, filtered and the solvent is removed under reduced pressure to give methanesulfonic acid phenethyl ester.

후처리

  1. customto reach room temperature
  2. customSolvent is removed under reduced pressure
  3. additionWater is added
  4. extractionthe aqueous phase is extracted three times with Et2O
  5. washThe organic phase is washed with water, brine
  6. dry with materialdried over magnesium sulphate
  7. filtrationfiltered
  8. customthe solvent is removed under reduced pressure

출처 및 근거

ORD 기록
ord-d6910f16b73e49cd9e87621c1a070bb6
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09255101B2

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