Dibenzyl 2-isopropyl-2-hydroxy-3-methylsuccinate → 2-Hydroxy-2-isopropyl-3-methylsuccinic acid
반응식
[CH:1]([C:4]([OH:27])([CH:15]([CH3:26])[C:16]([O:18]CC1C=CC=CC=1)=[O:17])[C:5]([O:7]CC1C=CC=CC=1)=[O:6])([CH3:3])[CH3:2]>O1CCCC1.[Pd]>[OH:27][C:4]([CH:1]([CH3:3])[CH3:2])([CH:15]([CH3:26])[C:16]([OH:18])=[O:17])[C:5]([OH:7])=[O:6]참가 물질
4
실험 절차
The dibenzyl 2-isopropyl-2-hydroxy-3-methylsuccinate thus obtained was dissolved in tetrahydrofuran (25 mL), and the solution was stirred in the presence of 10% palladium/carbon (120 mg) under hydrogen stream at room temperature for 15 h. The catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure to give 748 mg of 2-hydroxy-2-isopropyl-3-methylsuccinic acid as oil (quantitative).
후처리
- customThe catalyst was removed by filtration
- concentrationthe filtrate was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-e691a0c0dbfe4fa983fdb084ce3fcd17
- 출처 데이터셋
- uspto-grants-2016_02
- 특허 번호
- US09260375B2
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