Pyridine → N-(4-bromo-2-chlorophenyl)-3-chloropropanamide

HRID 1774841노트

반응식

HRID 1774841 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([Cl:9])[CH:3]=1.N1C=CC=CC=1.[Cl:16][CH2:17][CH2:18][C:19](Cl)=[O:20]>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:19](=[O:20])[CH2:18][CH2:17][Cl:16])=[C:4]([Cl:9])[CH:3]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 693643-Chloropropionyl chlorideHCID 6101694-Bromo-2-chloroaniline

생성물 1

HCID 43346898N-(4-bromo-2-chlorophenyl)-3-chloropropanamide수율 90%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-bromo-2-chloro-phenylamine (32 g, 0.15 mol) and pyridine (13.45 g, 0.17 mol) in DCM (200 mL) was added 3-chloropropionyl chloride (21.65 g, 0.17 mol) dropwise at 15° C. After stirring at room temperature for 1 hour, the mixture was washed with water and then hydrochloric acid (2 N, aqueous). The organic layer was dried over anhydrous Na2SO4, filtered, and concentrated in vacuo to afford title compound (10.9 g, yield: 90%) as a white solid.

후처리

  1. washthe mixture was washed with water
  2. dry with materialThe organic layer was dried over anhydrous Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-376d4e64907a4af691c7f643a8dc1947
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09260408B2

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