Iodine → HCID 178506572, 화합물

HRID 1774952노트

반응식

HRID 1774952 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:8]=[C:9]3[CH:15]=[N:14][NH:13][C:10]3=[CH:11][N:12]=2)[CH:2]=1.[OH-].[K+].[I:18]I>CN(C=O)C>[I:18][C:15]1[C:9]2[C:10](=[CH:11][N:12]=[C:7]([C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)[CH:8]=2)[NH:13][N:14]=1

참가 물질

5

반응물 3

HCID 807IodineHCID 14797Potassium HydroxideHCID 866766805-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridine

생성물 1

HCID 178506572HCID 178506572, 화합물수율 90%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

5-(Pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridine (196 g, 1 mol) was dissolved in 1000 mL DMF. KOH (112 g, 2 mol) was added. After stirring for 30 min, I2 (303 g, 1.2 mol) was added. The mixture was stirred for 1 h at room temperature. After reaction, the reaction was quenched with saturated aq. Na2S2O5 solution followed by the addition water (5 L). The solid was filtered and washed with water to give 3-iodo-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridine as a yellow solid (290 g, 90%)

후처리

  1. stirringThe mixture was stirred for 1 h at room temperature
  2. customAfter reaction
  3. customthe reaction was quenched with saturated aq. Na2S2O5 solution
  4. additionfollowed by the addition water (5 L)
  5. filtrationThe solid was filtered
  6. washwashed with water

출처 및 근거

ORD 기록
ord-823187ec546d44e9b922ffba1fd7348d
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09260425B2

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