참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Monosodium Citrate | HCID 23666341 | — |
| 반응물 | HCID 131734730 | HCID 131734730 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Tofacitinib Citrate | HCID 10174505 | 89.3% |
반응 단계
Amorphous tofacitinib hydrobromide (0.55 g) was dissolved in water (6 mL). The solution was treated with solid monosodium citrate (0.40 g, 1.69 mmol) and the resulting white suspension was stirred for 16 hours at 25° C. The suspension was filtered, washed with water (2×5 mL) and air-dried for 16 hours at 25° C. to yield 0.63 g of tofacitinib citrate as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09260438B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_02 |
|---|
| ORD ID | ord-749e280bbddb45d38834f9f5890e8c66 |
|---|
| 출처 메모 | uspto-grants-2016_02 |
|---|
