2-Amino-4-(trifluoromethyl)benzamide → 2-(4-chloro-2-ethylsulfanylphenyl)-7-trifluoromethyl-3H-quinazolin-4-one

HRID 1775266

반응식

HRID 1775266 반응식
[NH2:1][C:2]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[Cl:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=O)=[C:18]([S:24][CH2:25][CH3:26])[CH:17]=1.S(=O)(O)[O-].[Na+].C(=O)(O)[O-].[Na+]>O.CC(N(C)C)=O>[Cl:15][C:16]1[CH:23]=[CH:22][C:19]([C:20]2[NH:6][C:4](=[O:5])[C:3]3[C:2](=[CH:10][C:9]([C:11]([F:12])([F:13])[F:14])=[CH:8][CH:7]=3)[N:1]=2)=[C:18]([S:24][CH2:25][CH3:26])[CH:17]=1

참가 물질

7

반응물 4

HCID 697392-Amino-4-(trifluoromethyl)benzamideHCID 516892Sodium BicarbonateHCID 23665763Sodium BisulfiteHCID 1148635404-Chloro-2-ethylsulfanylbenzaldehyde

생성물 1

HCID 1369687502-(4-chloro-2-ethylsulfanylphenyl)-7-trifluoromethyl-3H-quinazolin-4-one수율 80.7%

시약·촉매·용매 2

HCID 962Water용매HCID 31374Dimethylacetamide용매

반응 조건

온도
150 °C

실험 절차

A mixture of 1.0 g of 2-amino-4-trifluromethylbenzamide, 944 mg of 4-chloro-2-ethylsulfanylbenzaldehyde, 765 mg of sodium bisulfite and 4 ml of DMA was stirred at 150° C. for 15 hours. A saturated aqueous sodium bicarbonate solution and water were added to the cooled reaction mixture, and the precipitated solid was filtered. The resulting solid was washed with water and n-hexane and then dried to obtain 1.46 g of 2-(4-chloro-2-ethylsulfanylphenyl)-7-trifluoromethyl-3H-quinazolin-4-one.

후처리

  1. filtrationthe precipitated solid was filtered
  2. washThe resulting solid was washed with water and n-hexane
  3. customdried

출처 및 근거

ORD 기록
ord-f5e32b9844ec419e83db4936c186d6bb
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09260436B2

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