Ethanol → 3-(2-Aminoethyl)-6-fluoro-5-methoxy-1H-indole-2-carboxylic acid

HRID 1775434노트

반응식

HRID 1775434 반응식
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]3[CH2:14][CH2:13][NH:12][C:11](=[O:15])[C:7]=3[NH:8]2)=[CH:4][C:3]=1[O:16][CH3:17].C([OH:20])C.[OH-].[K+]>O>[NH2:12][CH2:13][CH2:14][C:6]1[C:5]2[C:9](=[CH:10][C:2]([F:1])=[C:3]([O:16][CH3:17])[CH:4]=2)[NH:8][C:7]=1[C:11]([OH:20])=[O:15]

참가 물질

5

반응물 3

HCID 702EthanolHCID 14797Potassium Hydroxide2회HCID 616433HCID 616433, 화합물

생성물 1

HCID 6164323-(2-Aminoethyl)-6-fluoro-5-methoxy-1H-indole-2-carboxylic acid

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

To a mixture of 7-fluoro-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one (780 mg), ethanol (5.00 mL), and water (5.00 mL) was added potassium hydroxide (1.58 g), followed by stirring at 80° C. overnight. Potassium hydroxide (1.58 g) was added to the reaction mixture, followed by stirring at 100° C. for 6 hours. After cooling to room temperature, the solvent was evaporated under reduced pressure. The obtained residue was dissolved in water (10.0 mL), to the mixture was added acetic acid (3.00 mL), and the precipitated solid was collected by filtration and dried under reduced pressure to obtain 3-(2-aminoethyl)-6-fluoro-5-methoxy-1H-indole-2-carboxylic acid (607 mg) as a reddish brown solid.

후처리

  1. stirringby stirring at 100° C. for 6 hours
  2. temperatureAfter cooling to room temperature
  3. customthe solvent was evaporated under reduced pressure
  4. dissolutionThe obtained residue was dissolved in water (10.0 mL), to the mixture
  5. additionwas added acetic acid (3.00 mL)
  6. filtrationthe precipitated solid was collected by filtration
  7. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-009a54eb703a47618c578a868e0d79cc
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09260445B2

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