Acetic Acid → 3-(4-Methoxyphenyl)-2-methyl-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one

HRID 1775668노트

반응식

HRID 1775668 반응식
[NH2:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:5][S:4][C:3]=1[C:13]([NH:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1)=[O:14].[C:24](OCC)(OCC)(OCC)[CH3:25].C(O)(=O)C.C(OCC)C>CCOC(C)=O>[CH3:23][O:22][C:19]1[CH:18]=[CH:17][C:16]([N:15]2[C:13](=[O:14])[C:3]3[S:4][CH:5]=[C:6]([C:7]4[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=4)[C:2]=3[N:1]=[C:24]2[CH3:25])=[CH:21][CH:20]=1

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 3283Diethyl EtherHCID 66221Triethyl orthoacetateHCID 867298003-Amino-N-(4-methoxyphenyl)-4-phenylthiophene-2-carboxamide

생성물 1

HCID 783226943-(4-Methoxyphenyl)-2-methyl-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one수율 21%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

3-Amino-N-(4-methoxyphenyl)-4-phenylthiophene-2-carboxamide (57 mg, 0.18 mmol), triethyl orthoacetate (1 ml), and acetic acid (0.1 ml) were placed in a pressure bottle. The mixture was heated with stiffing at 160° C. for 18 hr. After the completion of the reaction was confirmed by TLC, the reaction mixture was cooled to room temperature and solidified with diethyl ether and EtOAc to give 13 mg (0.037 mmol, 21% yield) of the title compound.

후처리

  1. temperatureThe mixture was heated

출처 및 근거

ORD 기록
ord-ce52aa5e3eab4902988d9082d362f262
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09260448B2

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