1-(4-Bromo-3-methylphenyl)ethanone → 2-Bromo-1-(4-bromo-3-methylphenyl)ethanone

참여 물질

역할	이름	HCID	투입량
반응물	1-(4-Bromo-3-methylphenyl)ethanone	HCID 347124	—
반응물	Phenyltrimethylammonium bromide dibromide	HCID 17977687	—
용매	Tetrahydrofuran	HCID 8028	—
생성물	2-Bromo-1-(4-bromo-3-methylphenyl)ethanone	HCID 59166346	100%

반응 단계

Trimethyl phenylammonium tribromide (13 g, 0.036 mol) was added to a solution of 1-(4-bromo-3-methyl-phenyl)-ethanone (6.3 g, 0.030 mol) in THF (30 mL) and the reaction mixture was stirred at RT for 12 h, filtered, and concentrated to provide the title intermediate (8.6 g, 100% yield). 1H NMR (CDCl3, 400 MHz) δ (ppm): 7.82 (m, 1H), 7.66 (m, 2H), 4.38 (s, 2H), 2.56 (s, 3H)

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09260414B2
출처 데이터셋	uspto-grants-2016_02
ORD ID	ord-f045d3a9eb774e919dd2222e64f2203e
출처 메모	uspto-grants-2016_02