Methanesulfonyl chloride → HCID 86702165, 화합물

HRID 1776246노트

반응식

HRID 1776246 반응식
[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][CH2:6][CH:5]([NH2:9])[CH2:4]1.[CH3:10][S:11](Cl)(=[O:13])=[O:12]>N1C=CC=CC=1>[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][CH2:6][CH:5]([NH:9][S:11]([CH3:10])(=[O:13])=[O:12])[CH2:4]1

참가 물질

4

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 4099083-Methoxycyclohexan-1-amine

생성물 1

HCID 86702165HCID 86702165, 화합물수율 45%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a stirred solution of 3-methoxycyclohexanamine (0.200 g, 1.5 mmol) in pyridine (1 mL) was added methanesulfonyl chloride (0.144 mL, 1.9 mmol). The reaction mixture was stirred at room temperature for 16 hrs and then concentrated. The mixture was diluted with ethyl acetate and washed with 1 N aqueous hydrochloric acid, saturated aqueous sodium bicarbonate, saturated aqueous sodium chloride, dried (anhydrous sodium sulfate), filtered, and concentrated to afford the product as a brown oil (0.140 g, 44%). The material was used without further purification.

후처리

  1. concentrationconcentrated
  2. additionThe mixture was diluted with ethyl acetate
  3. washwashed with 1 N aqueous hydrochloric acid, saturated aqueous sodium bicarbonate, saturated aqueous sodium chloride
  4. dry with materialdried (anhydrous sodium sulfate)
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-bcf2eab0cab446dca1017bad20bc964e
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09265772B2

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