Carbon Dioxide → 2-(prop-2-yn-1-yl)pent-4-ynoic acid

반응식

[CH2:1]([C:4]([CH2:11][C:12]#[CH:13])(C(O)=O)[C:5]([OH:7])=[O:6])[C:2]#[CH:3].C(=O)=O>>[CH2:1]([CH:4]([CH2:11][C:12]#[CH:13])[C:5]([OH:7])=[O:6])[C:2]#[CH:3]

참가 물질

반응물 2

HCID 280Carbon Dioxide

HCID 12686700HCID 12686700, 화합물

생성물 1

HCID 136736532-(prop-2-yn-1-yl)pent-4-ynoic acid수율 79.9%

실험 절차

The dipropargylmalonic acid (26 gm, 0.443 mol) was heated neat at 135 C until CO2 stopped evolving. It was then allowed to cool to an oil. The oil was distilled at 0.5 psi. The remaining oily residue in the distillation flask and solid were combined (15.7 gm, 79.9% yield) and was used as is in the next step.

후처리

temperatureto cool to an oil
distillationThe oil was distilled at 0.5 psi

출처 및 근거

ORD 기록: ord-06bb52966caa440bb7db883f19e241cb
출처 데이터셋: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09265838B2

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