Potassium Carbonate → HCID 86679497, 화합물

HRID 1776541노트

반응식

HRID 1776541 반응식
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([C:7]([O:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:8])=[CH:5][C:4]=1[NH:19][S:20]([CH3:23])(=[O:22])=[O:21].Br[CH2:25][C:26]([NH2:28])=[O:27].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.O>[NH2:28][C:26](=[O:27])[CH2:25][N:19]([C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][C:3]=1[O:2][CH3:1])[C:7]([O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:8])[S:20]([CH3:23])(=[O:22])=[O:21]

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 696322-BromoacetamideHCID 86679496HCID 86679496, 화합물

생성물 1

HCID 86679497HCID 86679497, 화합물수율 94.1%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

Benzyl 4-methoxy-3-(methylsulfonamido)benzoate (200 mg, 0.596 mmol) was dissolved in DMF (2 ml). 2-bromoacetamide (247 mg, 1.789 mmol) and K2CO3 (165 mg, 1.193 mmol) were added, and the reaction was stirred at RT overnight. The reaction mixture was diluted with water and filtered. The precipitate was washed with water and dried in the vacuum oven to give benzyl 3-(N-(2-amino-2-oxoethyl)methylsulfonamido)-4-methoxybenzoate (220 mg, 94% yield).

후처리

  1. filtrationfiltered
  2. washThe precipitate was washed with water
  3. customdried in the vacuum oven

출처 및 근거

ORD 기록
ord-6eea3b353b88478cb6e8c8b01b8275a8
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09265768B2

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