p-Toluenesulfonic acid → HCID 86728242, 화합물

HRID 1776833노트

반응식

HRID 1776833 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([C:9]2[NH:10][C:11]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH:3]=1.[CH3:18][C:19]1C=CC(S(O)(=O)=O)=C[CH:24]=1>CC(C)=O>[Br:1][C:2]1[CH:3]=[C:4]2[C:9]3[NH:10][C:11]4[C:16]([C:17]=3[C:19]([CH3:24])([CH3:18])[O:8][C:5]2=[CH:6][CH:7]=1)=[CH:15][CH:14]=[CH:13][CH:12]=4

참가 물질

4

반응물 2

HCID 6101p-Toluenesulfonic acidHCID 13163448HCID 13163448, 화합물

생성물 1

HCID 86728242HCID 86728242, 화합물수율 391.7%

시약·촉매·용매 1

HCID 180Acetone용매

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온도
150 °C

실험 절차

To the solution of 4-bromo-2-(1H-indol-2-yl)phenol (200 mg, 0.69 mmol) in acetone (5 mL) was added PTSA (26 mg, 0.14 mmol), it was stirred at 150° C. in a sealed tube. Then the solvent was removed and the crude product was purified using prep-TLC to provide the desired product of 2-bromo-6,6-dimethyl-6,11-dihydrochromeno[4,3-b]indole (180 mg, yield: 79.3%). MS (M+H)+: 327/329.

후처리

  1. customThen the solvent was removed
  2. customthe crude product was purified

출처 및 근거

ORD 기록
ord-504ee3965bda4e8c96961e0d04b2ba5d
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09265773B2

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