5-(11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide → HCID 178464693, 화합물

HRID 1776912

반응식

HRID 1776912 반응식
[F:1][C:2]1[C:3]2[CH:4]=[C:5]3[C:14]4[N:15]=[C:16]([C:19]5[C:20]([N:38]([CH3:43])[S:39]([CH3:42])(=[O:41])=[O:40])=[CH:21][C:22]6[O:26][C:25]([C:27]7[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=7)=[C:24]([C:34]([NH2:36])=[O:35])[C:23]=6[CH:37]=5)[CH:17]=[CH:18][C:13]=4[O:12][CH2:11][N:6]3[C:7]=2[CH:8]=[CH:9][CH:10]=1>CC(N(C)C)=O.CC(N(C)C)=O>[CH3:7][N:6]([CH3:11])/[C:5](=[N:36]\[C:34]([C:24]1[C:23]2[CH:37]=[C:19]([C:16]3[CH:17]=[CH:18][C:13]4[O:12][CH2:11][N:6]5[C:7]6[CH:8]=[CH:9][CH:10]=[C:2]([F:1])[C:3]=6[CH:4]=[C:5]5[C:14]=4[N:15]=3)[C:20]([N:38]([CH3:43])[S:39]([CH3:42])(=[O:41])=[O:40])=[CH:21][C:22]=2[O:26][C:25]=1[C:27]1[CH:28]=[CH:29][C:30]([F:33])=[CH:31][CH:32]=1)=[O:35])/[CH3:4]

참가 물질

3

반응물 1

HCID 867282905-(11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

생성물 1

HCID 178464693HCID 178464693, 화합물

시약·촉매·용매 1

HCID 19097097DMA dimethylacetamide용매

실험 절차

To a solution of 5-(11-fluoro-6H-pyrido[2′,3′:5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide (100 mg, 0.17 mmol) in DMA-DMA (2 mL) was stirred at 120° C. for 2 hour. The reaction mixture was concentrated in vacuo and the resulting residue was used to the next step without further purification.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe resulting residue was used to the next step without further purification

출처 및 근거

ORD 기록
ord-7a6b57e5fa0143a58a6302e47794454f
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09265773B2

연결된 노트

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