Triethylamine → 3-Nitrooxy-propyl propionate
반응식
[C:1](Cl)(=[O:4])[CH2:2][CH3:3].[N+:6]([O:9][CH2:10][CH2:11][CH2:12][OH:13])([O-:8])=[O:7].C(N(CC)CC)C>>[C:1]([O:13][CH2:12][CH2:11][CH2:10][O:9][N+:6]([O-:8])=[O:7])(=[O:4])[CH2:2][CH3:3]참가 물질
4
반응 조건
- 온도
- 3 °C
실험 절차
9.1 mmol Propionyl chloride were dissolved in 10 ml TMBE and cooled to 3° C. 8.25 mmol 3-Nitrooxypropanol and 9.1 mmol triethylamine in 5 ml TMBE were dropped over a period of 5 min at 3 to 6° C. After 2 hours and 30 minutes stirring without cooling the reaction mixture were extracted with 1N HCl, twice with water, washed with brine, dried over Na2SO4 and the solvent was removed in vacuo leaving 1.35 g.
후처리
- temperaturewithout cooling the reaction mixture
- extractionwere extracted with 1N HCl, twice with water
- washwashed with brine
- dry with materialdried over Na2SO4
- customthe solvent was removed in vacuo
- customleaving 1.35 g
출처 및 근거
- ORD 기록
- ord-13f5218e071a4db9895e100498acb3de
- 출처 데이터셋
- uspto-grants-2016_02
- 특허 번호
- US09266814B2
반응 노트
불러오는 중…