P-Cresol → Ethyl (p-tolyloxy)acetate

HRID 1777099

반응식

HRID 1777099 반응식
[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[C:3]([CH3:8])[CH:2]=1.Br[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12].C([O-])([O-])=O.[K+].[K+]>CC#N>[C:3]1([CH3:8])[CH:4]=[CH:5][C:6]([O:7][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:1][CH:2]=1

참가 물질

5

반응물 3

HCID 2879P-CresolHCID 7748Ethyl bromoacetateHCID 11430Potassium Carbonate

생성물 1

HCID 4047281Ethyl (p-tolyloxy)acetate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
80 °C

실험 절차

To a mixture of p-cresol (500 mg, 4.63 mmol) and ethyl 2-bromoacetate (928 mg, 5.56 mmol) in CH3CN (10 mL) was added K2CO3 (3 g, 21.7 mmol). The reaction mixture was stirred at 80° C. for 4 h. The solid was removed by filtration and the filtrate was concentrated to give the title compound which was used in the next step without further purification.

후처리

  1. customThe solid was removed by filtration
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-ae7cc55cd61e4573944615b91447b282
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09266836B2

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