Ethyl bromoacetate → HCID 90241046, 화합물

HRID 1777178노트

반응식

HRID 1777178 반응식
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:7]2.C([O-])([O-])=O.[K+].[K+].Br[CH2:26][C:27]([O:29][CH2:30][CH3:31])=[O:28]>CC#N>[CH2:30]([O:29][C:27]([CH2:26][O:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:7]2)=[O:28])[CH3:31]

참가 물질

5

반응물 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 10538586tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

생성물 1

HCID 90241046HCID 90241046, 화합물수율 90%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of tert-butyl 3,4-dihydro-5-hydroxyisoquinoline-2(1H)-carboxylate (750 mg, 3.01 mmol) and K2CO3 (498 mg, 3.61 mmol) in MeCN was added ethyl 2-bromoacetate (603 mg, 3.61 mmol). The mixture was stirred at room temperature overnight, the mixture was then filtered and the filtrate was concentrated under vacuum to give the desired product (900 mg, 90%). LCMS (m/z): 336.2 [M+H]+.

후처리

  1. filtrationthe mixture was then filtered
  2. concentrationthe filtrate was concentrated under vacuum

출처 및 근거

ORD 기록
ord-11ac80ecd0964da59f8c6cb1b56711af
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09266836B2

반응 노트

불러오는 중…