HCID 90241046, 화합물 → HCID 90241000, 화합물

HRID 1777179노트

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HRID 1777179 반응식
[CH2:1]([O:3][C:4](=[O:24])[CH2:5][O:6][C:7]1[CH:16]=[CH:15][CH:14]=[C:13]2[C:8]=1[CH2:9][CH2:10][N:11](C(OC(C)(C)C)=O)[CH2:12]2)[CH3:2]>C(OCC)(=O)C>[CH2:12]1[C:13]2[C:8](=[C:7]([O:6][CH2:5][C:4]([O:3][CH2:1][CH3:2])=[O:24])[CH:16]=[CH:15][CH:14]=2)[CH2:9][CH2:10][NH:11]1

참가 물질

3

반응물 1

HCID 90241046HCID 90241046, 화합물

생성물 1

HCID 90241000HCID 90241000, 화합물수율 98.2%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
25 °C

실험 절차

To a solution of tert-butyl 5-(2-ethoxy-2-oxoethoxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate (400 mg, 1.19 mmol) in ethyl acetate (10 mL), cooled in an ice-water bath, was added (10 mL, 1N) drop wise. The mixture was stirred at 25° C. for 16 h and then concentrated under vacuum to give the crude product (275 mg, 98%) which was used to the next step without further purification.

후처리

  1. additionwas added (10 mL, 1N) drop wise
  2. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-89a015e037ac4f6dbcb95b1c1a1b65f1
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09266836B2

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