{4-[5-(2-Chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-phenyl}-methanol → 4-[5-(2-Chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-benzaldehyde

HRID 1777369노트

반응식

HRID 1777369 반응식
[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1.[Cl:12][C:13]1[CH:18]=[C:17]([C:19]2[O:23][N:22]=[C:21]([C:24]3[CH:29]=[CH:28][C:27]([CH2:30][OH:31])=[CH:26][CH:25]=3)[N:20]=2)[CH:16]=[CH:15][C:14]=1[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>ClCCl>[Cl:12][C:13]1[CH:18]=[C:17]([C:19]2[O:23][N:22]=[C:21]([C:24]3[CH:29]=[CH:28][C:27]([CH:30]=[O:31])=[CH:26][CH:25]=3)[N:20]=2)[CH:16]=[CH:15][C:14]=1[C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1

참가 물질

4

반응물 2

HCID 70869544{4-[5-(2-Chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-phenyl}-methanolHCID 178418287HCID 178418287, 화합물

생성물 1

HCID 867151454-[5-(2-Chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-benzaldehyde

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Pyridiniumchlorochromate (3.6 g, 0.017 mol) is added to a solution of {4-[5-(2-chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-phenyl}-methanol (4.0 g, 0.011 mol) in dichloromethane (40 mL). The reaction mixture is stirred at room temperature for 30 minutes, filtered and washed with dichloromethane (40 mL). Filtrate is concentrated under reduced pressure to give crude which is purified by column chromatography (230; 400 mesh: 9.5:0.5 toluene:ethyl acetate) to yield 4-[5-(2-chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-benzaldehyde.

후처리

  1. filtrationfiltered
  2. washwashed with dichloromethane (40 mL)
  3. concentrationFiltrate is concentrated under reduced pressure
  4. customto give crude which
  5. customis purified by column chromatography (230; 400 mesh: 9.5:0.5 toluene:ethyl acetate)

출처 및 근거

ORD 기록
ord-d7a052f0dc084490a71bb912ab50e8a8
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09266867B2

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