Pyridine → Methyl 4-(3-fluorophenoxy)benzoate

HRID 1777578노트

반응식

HRID 1777578 반응식
[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][CH:3]=1.[F:12][C:13]1[CH:14]=[C:15](B(O)O)[CH:16]=[CH:17][CH:18]=1.N1C=CC=CC=1>ClCCl.C([O-])(=O)C.[Cu+2].C([O-])(=O)C>[F:12][C:13]1[CH:18]=[C:17]([CH:16]=[CH:15][CH:14]=1)[O:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:10][CH:11]=1

참가 물질

6

반응물 3

HCID 1049PyridineHCID 7456MethylparabenHCID 27339863-Fluorophenylboronic acid

생성물 1

HCID 67973924Methyl 4-(3-fluorophenoxy)benzoate

시약·촉매·용매 2

HCID 8895Cupric acetate촉매HCID 6344Dichloromethane용매

실험 절차

A mixture of methyl 4-hydroxybenzoate (0.400 g; 2.63 mmol), 3-fluorobenzene boronic acid (0.735 g; 5.26 mmol), copper acetate (0.955 g; 5.26 mmol) and pyridine (0.425 mL; 5.26 mmol) in dichloromethane (15 mL) was stirred at room temperature overnight. The reaction mixture was filtered and concentrated under reduced pressure.

후처리

  1. filtrationThe reaction mixture was filtered
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-cb1f2ccb3941421198d896d3ed1b911d
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09266832B2

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