Chlorosuccinimide → HCID 89726263, 화합물

HRID 1777735노트

반응식

HRID 1777735 반응식
[N:1]1([CH2:10][C:11]([OH:13])=[O:12])[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[CH:2]1.C1C(=O)N([Cl:21])C(=O)C1>CC#N>[Cl:21][C:3]1[C:4]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[N:1]([CH2:10][C:11]([OH:13])=[O:12])[CH:2]=1

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 22139374(1H-Pyrrolo[2,3-b]pyridin-1-yl)acetic acid

생성물 1

HCID 89726263HCID 89726263, 화합물수율 77%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
65 °C

실험 절차

To a suspension of 2-(1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acid (100 mg) in MeCN (10 mL) was added NCS (91 mg) and the reaction mixture was stirred at 60° C. overnight and at 65° C. for 20 h. The solvent was removed in vacuo, the residue was taken up in DCM and the resulting precipitate was filtered off. The precipitate was further washed with DCM and dried in vacuo. 92 mg of grey solid was obtained. LC-MS (B): tR=0.66 min; [M+H]+: 211.02.

후처리

  1. customThe solvent was removed in vacuo
  2. filtrationthe resulting precipitate was filtered off
  3. washThe precipitate was further washed with DCM
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-239a59c217984798aad5e05da56dbf7a
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09266876B2

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