Dimethylformamide → (S)-N-(5-cyano-4-(2-methoxyethoxy)pyridin-2-yl)-7-formyl-2-methyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide

HRID 1778110노트

반응식

HRID 1778110 반응식
C1(O[C:8](=[O:23])[NH:9][C:10]2[CH:15]=[C:14]([O:16][CH2:17][CH2:18][O:19][CH3:20])[C:13]([C:21]#[N:22])=[CH:12][N:11]=2)C=CC=CC=1.C(C1C=CC(NC([N:35]2[CH2:41][CH2:40][CH2:39][CH2:38][C:37]3[CH:42]=[CH:43][C:44]([CH:46]([O:49]C)OC)=[N:45][C:36]2=3)=O)=NC=1)#N.[CH3:51][N:52]([CH:54]=[O:55])[CH3:53]>>[C:21]([C:13]1[C:14]([O:16][CH2:17][CH2:18][O:19][CH3:20])=[CH:15][C:10]([NH:9][C:8]([N:35]2[C:36]3[C:37](=[CH:42][C:43]([CH2:51][N:52]4[CH2:53][CH2:53][N:52]([CH3:54])[CH2:51][C:54]4=[O:55])=[C:44]([CH:46]=[O:49])[N:45]=3)[CH2:38][CH2:39][C@@H:41]2[CH3:40])=[O:23])=[N:11][CH:12]=1)#[N:22]

참가 물질

4

반응물 3

HCID 6228DimethylformamideHCID 118037151N-(5-cyanopyridin-2-yl)-2-(dimethoxymethyl)-7,8-dihydro-5H-pyrido[2,3-b]azepine-9(6H)-carboxamideHCID 125470569Phenyl (5-cyano-4-(2-methoxyethoxy)pyridin-2-yl)carbamate

생성물 1

HCID 118036665(S)-N-(5-cyano-4-(2-methoxyethoxy)pyridin-2-yl)-7-formyl-2-methyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide

실험 절차

From intermediates 108 and 268, coupled and deprotected in an analogous manner to intermediate 236, but using DMF instead of THF, and Example 201. The title compound was obtained as a light yellow-brown solid.

출처 및 근거

ORD 기록
ord-67dfb88aeb8f4121874dfd0f4b79f165
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09266883B2

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