Trimethyl orthoacetate → HCID 86719150, 화합물
반응식
[Br:1][C:2]1[N:3]=[C:4]([Cl:10])[C:5]([NH:8][NH2:9])=[N:6][CH:7]=1.[C:11](OC)(OC)(OC)[CH3:12]>O>[Br:1][C:2]1[N:3]=[C:4]([Cl:10])[C:5]2[N:6]([C:11]([CH3:12])=[N:9][N:8]=2)[CH:7]=1참가 물질
4
반응 조건
- 온도
- 130 °C
실험 절차
5-bromo-3-chloro-2-hydrazinylpyrazine 1′-1 (945 mg; 3.51 mmol) is dissolved in 12 ml trimethyl orthoacetate and heated up to 130° C. for 1 hour. The solution is diluted with water and extracted with EtOAc. The organic phase is then purified with flash chromatography: cHex/EtOAc=70%/30% to 55%/45% within 10 column volumes.
후처리
- extractionextracted with EtOAc
- customThe organic phase is then purified with flash chromatography
출처 및 근거
- ORD 기록
- ord-8153cb52768c4ee89ccf5b14ef7f701e
- 출처 데이터셋
- uspto-grants-2016_02
- 특허 번호
- US09266891B2
반응 노트
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