Trifluoroacetic acid → 1-(2,2,2-Trifluoroethyl)piperidin-4-amine 2,2,2-trifluoroacetate

HRID 1778227노트

반응식

HRID 1778227 반응식
[F:1][C:2]([F:19])([F:18])[CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([NH:10]C(=O)OC(C)(C)C)[CH2:6][CH2:5]1.[C:20]([OH:26])([C:22]([F:25])([F:24])[F:23])=[O:21]>ClCCl>[F:23][C:22]([F:25])([F:24])[C:20]([OH:26])=[O:21].[F:19][C:2]([F:1])([F:18])[CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([NH2:10])[CH2:6][CH2:5]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 22562166tert-Butyl 1-(2,2,2-trifluoroethyl)piperidin-4-ylcarbamate

생성물 1

HCID 1183240701-(2,2,2-Trifluoroethyl)piperidin-4-amine 2,2,2-trifluoroacetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Into a 50-mL round-bottom flask, was placed tert-butyl N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]carbamate (2.0 g, 7.08 mmol, 1.00 equip), dichloromethane (20 mL), and CF3COOH (4 mL). The resulting solution was stirred overnight at room temperature. The resulting mixture was concentrated under vacuum to yield 1-(2,2,2-trifluoroethyl)piperidin-4-amine 2,2,2-trifluoroacetate as a yellow oil. (ES, m/z) 183 [M+H]+

후처리

  1. customInto a 50-mL round-bottom flask, was placed
  2. concentrationThe resulting mixture was concentrated under vacuum

출처 및 근거

ORD 기록
ord-d2aaff3471bb4580ae8567f251ef6e20
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09266835B2

반응 노트

불러오는 중…