Trifluoroacetic acid → 3-Azetidinol, 3-acetate, 2,2,2-trifluoroacetate (1:1)
반응식
[C:1]([O:4][CH:5]1[CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1)(=[O:3])[CH3:2].[C:16]([OH:22])([C:18]([F:21])([F:20])[F:19])=[O:17]>C(Cl)Cl>[F:19][C:18]([F:21])([F:20])[C:16]([OH:22])=[O:17].[NH:7]1[CH2:8][CH:5]([O:4][C:1](=[O:3])[CH3:2])[CH2:6]1참가 물질
4
실험 절차
To a solution of tert-butyl 3-acetoxyazetidine-1-carboxylate (Intermediate 95, 0.914 g) in DCM (5 mL) was added TFA (5 mL) and the mixture was stirred at room temperature for 30 minutes. The resultant mixture was concentrated in vacuo and azeotroped with toluene and diethyl ether to give acetic acid azetidin-3-yl ester trifluoroacetate salt (1.40 g) as a clear oil.
후처리
- concentrationThe resultant mixture was concentrated in vacuo
- customazeotroped with toluene and diethyl ether
출처 및 근거
- ORD 기록
- ord-efa45ac8e05a41dbac28ca9a9c221eb9
- 출처 데이터셋
- uspto-grants-2016_02
- 특허 번호
- US09266896B2
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