Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Ethyl 1-morpholinocyclohexanecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Bis(2-bromoethyl) ether | HCID 21521 | — |
| 반응물 | Ethyl 1-aminocyclohexane-1-carboxylate hydrochloride | HCID 11241228 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Ethyl 1-morpholinocyclohexanecarboxylate | HCID 86681323 | — |
반응 단계
Ethyl 1-aminocyclohexancarboxylate hydrogen chloride (5.800 g), triethylamine (13.62 mL) and 1-bromo-2-(2-bromoethoxy)ethane (4.21 mL) were stirred together in N,N-dimethylformamide (50 mL) at 95° C. overnight. The reaction mixture was diluted with ethyl acetate (150 mL), washed with water (100 mL) and brine (100 mL), dried over magnesium sulfate, filtered, and concentrated. Silica gel chromatography eluting with a gradient of 5% to 25% ethyl acetate/hexanes provided the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09266877B2 |
| 출처 데이터셋 | uspto-grants-2016_02 |
| ORD ID | ord-8937afdeb1bd42099cd0d560abb315d5 |
| 출처 메모 | uspto-grants-2016_02 |