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Methanol → HCID 19050666, 화합물

HRID 1779306
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HRID 1779306 반응식
[CH3:1][C:2]1([CH3:22])[CH2:6][O:5][C:4]([C:7]2[CH:21]=[CH:20][CH:19]=[CH:18][C:8]=2[CH2:9][C:10]2[N:15]=[C:14](Cl)[CH:13]=[C:12](Cl)[N:11]=2)=[N:3]1.[O:23]([CH3:25])[Na].[CH3:26][OH:27]>C1(C)C=CC=CC=1.O>[CH3:1][C:2]1([CH3:22])[CH2:6][O:5][C:4]([C:7]2[CH:21]=[CH:20][CH:19]=[CH:18][C:8]=2[CH2:9][C:10]2[N:15]=[C:14]([O:27][CH3:26])[CH:13]=[C:12]([O:23][CH3:25])[N:11]=2)=[N:3]1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 887MethanolHCID 190506632(2-(4,4-Dimethyl-oxazolin-2-yl)-benzyl)-4,6-dichloropyrimidineHCID 178418582HCID 178418582, 화합물

생성물 1

HCID 19050666HCID 19050666, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 1140Toluene용매

반응 조건

온도
65 °C

실험 절차

To a solution of 1.7 g of 2(2-(4,4-dimethyl-oxazolin-2-yl)-benzyl)-4,6-dichloropyrimidine in 100 ml of methanol are added 2.18 g of 25% methanolic NaOCH3 and the mixture heated for 10 hrs at 65° C. with stirring. The temperature is lowered to 60° and stirring continued overnight. The solvent is stripped and the residue taken up in 80 ml of toluene and 50 ml of water. The toluene layer was separated and washed with 50 ml of water, separated and concentrated to give the title compound as a yellow oil.

후처리

  1. customis lowered to 60°
  2. stirringstirring continued overnight
  3. customThe toluene layer was separated
  4. washwashed with 50 ml of water
  5. customseparated
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ac26d21e37ca4140a7f6d41a2a3873e0
출처 데이터셋
uspto-grants-1997_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05627137

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