Hydrofluoric Acid → HCID 131720010, 화합물

HRID 1779941노트

반응식

HRID 1779941 반응식
[Si]([O:8][C@H:9]1[CH2:35][CH2:34][C@@:33]2([CH3:36])[C@@H:11]([CH2:12][CH2:13][C@@H:14]3[C@@H:32]2[C@@H:31]([O:37][Si](C)(C)C)[C:30](=O)[C@@:29]2([CH3:43])[C@H:15]3[CH2:16][C@@H:17]3[O:22][C@@:21]4([O:28][CH2:27][C@H:25]([CH3:26])[CH2:24][CH2:23]4)[C@@H:19]([CH3:20])[C@@H:18]32)[CH2:10]1)(C(C)(C)C)(C)C.F.C[C@@H]1[C@]2(OC[C@H](C)CC2)O[C@H]2C[C@@H]3[C@@](C)([C@@H]12)[C@H]([OH:66])C(=O)[C@H]1[C@H]3CC[C@@H]2[C@]1(C)CC[C@H](O)C2>C(#N)C>[CH3:20][C@@H:19]1[C@:21]2([O:28][CH2:27][C@H:25]([CH3:26])[CH2:24][CH2:23]2)[O:22][C@H:17]2[C:16](=[O:66])[C@@H:15]3[C@@:29]([CH3:43])([C@@H:18]12)[CH2:30][C@H:31]([OH:37])[C@H:32]1[C@H:14]3[CH2:13][CH2:12][C@@H:11]2[C@:33]1([CH3:36])[CH2:34][CH2:35][C@H:9]([OH:8])[CH2:10]2

참가 물질

5

반응물 3

HCID 14917Hydrofluoric AcidHCID 15891086023-87-2HCID 54210416HCID 54210416, 화합물

생성물 1

HCID 131720010HCID 131720010, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

The title compound was synthesized from (3β,5α,11β,25R)-3-(t-butyidimethylsilyloxy)-11-(trimethylsilyloxy)spirostan-12-one was desilylated with hydrofluoric acid in acetonitrile according to the procedure described in J. Am. Chem. Soc., 1972, 94, 6190. The title compound must be carefully handled because it will rearrange to (3β,5α,12β,25R)-spirostan-3,12-diol-11-one if exposed to base.

출처 및 근거

ORD 기록
ord-ad146eecb5f64df696f4ec09ecd75c71
출처 데이터셋
uspto-grants-1997_05
특허 번호
US05629295

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