Iodoethanol → 1-(2-Hydroxyethyl)-1-methyl-4-(benzoxazol-2-yl)homo-piperazinium iodide

HRID 1780669노트

반응식

HRID 1780669 반응식
[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][N:5]([C:9]2[O:10][C:11]3[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)[CH2:4][CH2:3]1.[I:18][CH2:19][CH2:20][OH:21]>C1COCC1>[I-:18].[OH:21][CH2:20][CH2:19][N+:2]1([CH3:1])[CH2:8][CH2:7][CH2:6][N:5]([C:9]2[O:10][C:11]3[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)[CH2:4][CH2:3]1

참가 물질

4

반응물 2

HCID 12225IodoethanolHCID 105856212-(4-Methyl-1-homopiperazinyl)benzoxazole

생성물 1

HCID 190472761-(2-Hydroxyethyl)-1-methyl-4-(benzoxazol-2-yl)homo-piperazinium iodide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A 100 mg portion of 2-(4-methyl-1-homopiperazinyl)-benzoxazole was dissolved in 3 ml of THF. Under cooling with ice, 89 mg of 2-iodoethyl alcohol was added to the thus prepared solution, and the reaction was carried out for 1 hour at the same temperature and then for 29 hours at room temperature. The reaction solution was concentrated under a reduced pressure, and 3 ml of acetone was added to the resulting residue. The precipitate thus formed was collected by filtration, washed with acetone and then dried to obtain 143 mg of the title compound.

후처리

  1. additionwas added to the thus prepared solution
  2. waitfor 29 hours at room temperature
  3. concentrationThe reaction solution was concentrated under a reduced pressure, and 3 ml of acetone
  4. additionwas added to the resulting residue
  5. customThe precipitate thus formed
  6. filtrationwas collected by filtration
  7. washwashed with acetone
  8. customdried

출처 및 근거

ORD 기록
ord-3c1c44bac39e4726bd010ab1cffe6729
출처 데이터셋
uspto-grants-1997_05
특허 번호
US05631257

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