1-Butanesulfonyl chloride → 2-Butanesulfonyloxydodecanoic acid

HRID 1780700

반응식

HRID 1780700 반응식
[OH:1][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[C:3]([OH:5])=[O:4].[CH2:16]([S:20](Cl)(=[O:22])=[O:21])[CH2:17][CH2:18][CH3:19]>N1C=CC=CC=1>[CH2:16]([S:20]([O:1][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[C:3]([OH:5])=[O:4])(=[O:22])=[O:21])[CH2:17][CH2:18][CH3:19]

참가 물질

4

반응물 2

HCID 754301-Butanesulfonyl chlorideHCID 97783Hydroxylauric Acid

생성물 1

HCID 190472202-Butanesulfonyloxydodecanoic acid

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

2-Hydroxydodecanoic acid (1 g) dissolved in a 10% methanolic hydrochloric acid solution was stirred at room temperature for 1 hour. The mixture was then concentrated and distributed into chloroform and water, and the chloroform layer was washed with a 1% aqueous sodium hydrogen carbonate solution and water, dried with anhydrous sodium sulfate and concentrated to give the methyl ester of 2-hydroxydodecanoic acid (1.02 g). To the methyl ester of 2-hydroxydodecanoic acid dissolved in pyridine (20 ml) was added butanesulfonyl chloride (0.80 g), and the mixture was stirred for 8 hours. Then, the pyridine was removed by distillation, and the residue was distributed into chloroform and water. The chloroform layer was dried with anhydrous sodium sulfate, concentrated and subjected-to chromatography on a silica gel column with an eluent system of n-hexane-ethyl acetate (50:1) to give the methyl ester of 2-butanesulfonyloxydodecanoic acid (1.21 g).

후처리

  1. customThen, the pyridine was removed by distillation
  2. dry with materialThe chloroform layer was dried with anhydrous sodium sulfate
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d865f6537bee4af98d82b0b8f1ae0c5b
출처 데이터셋
uspto-grants-1997_05
특허 번호
US05631238

연결된 노트

불러오는 중…