2',3'-Dimethyl-3-nitrobenzanilide → 3-amino-N-(2,3-dimethylphenyl)benzamide

HRID 1780804

반응식

HRID 1780804 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:18]=[CH:19][CH:20]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[C:11]=1[CH3:17])=[O:8])([O-])=O.[H][H]>CO.O1CCCC1.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:18]=[CH:19][CH:20]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[C:11]=1[CH3:17])=[O:8]

참가 물질

6

반응물 2

HCID 8165712',3'-Dimethyl-3-nitrobenzanilideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 64565863-amino-N-(2,3-dimethylphenyl)benzamide

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 1 (1 g) in 70 mL methanol and 30 mL of tetrahydrofuran was added 10% Pd/C (0.2 g) under nitrogen atmosphere. Hydrogen was applied to the mixture at 60 psi for 16 h. The mixture was filtered and concentrated in vacuo to obtain the product. NMR (300 MHz, CDCl3) δ 7.71 (1H, s), 7.55 (1H, d, J=9 Hz), 7.23 (1H, t, J=9 Hz), 7.19 (1H, s), 7.14 (1H, t, J=9 Hz), 7.04 (1H, d, J=9 Hz), 6.82 (1H, d, J=9 Hz), 3.84 (2H, b), 2.32 (3H, s), 2.20 (2H, s).

후처리

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated in vacuo
  3. customto obtain the product

출처 및 근거

ORD 기록
ord-cbf59ca0dd2742b38f7a171f2f89ecae
출처 데이터셋
uspto-grants-1997_05
특허 번호
US05631280

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