Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Propylene Oxide → 10-(2-Hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Propylene Oxide | HCID 6378 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 1,4,7-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane | HCID 107830 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 10-(2-Hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid | HCID 60715 | 96% |
반응 단계
To a solution of 194.0 g (0.56 mol) of 15 in 450 mL of water is added sufficient NaOH to adjust the pH to 12.0 to 12.5 (the temperature is maintained below 30° C. during the addition). Propylene oxide (65 g, 1.12 mols) is added to the basic solution. After 6 hours at ambient temperature the excess propylene oxide and solvent is removed under reduced pressure. The product is precipitated from a minimal amount of methanol to afford 16 in 96% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05631368 |
| 출처 데이터셋 | uspto-grants-1997_05 |
| ORD ID | ord-de6058ab8e8a475cb7537815b0489c23 |
| 출처 메모 | uspto-grants-1997_05 |