참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dihydroxyacetone | HCID 670 | — |
| 반응물 | Ammonium Hydroxide | HCID 14923 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 5-Bromo-2-methoxy-benzamidine | HCID 10353755 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-(5-Bromo-2-methoxyphenyl)-4-hydroxymethylimidazole | HCID 10334004 | — |
반응 단계
A mixture of 5-Bromo-2-methoxy-benzamidine (1.5 g), 1,3-dihydroxy-acetone dimer (1.0 g), ammonium chloride (1.3 g), tetrahydrofuran (3 mL) and concentrated aqueous ammonium hydroxide (10 mL) was heated at 90° C. for 3 h. The reaction mixture was chilled on ice and the precipitated product was collected and recrystallized from methanol to afford 2-(5-Bromo-2-methoxyphenyl)-5-hydroxymethyl-imidazole as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05633376 |
|---|
| 출처 데이터셋 | uspto-grants-1997_05 |
|---|
| ORD ID | ord-d974bf9235d9408fbea0e1003a2cf886 |
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| 출처 메모 | uspto-grants-1997_05 |
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