Water → 1,2-Benzisothiazol-3(2H)-one

HRID 1781616

반응식

HRID 1781616 반응식
C[S:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[C:5]#[N:6].O.S(Cl)(Cl)(=O)=[O:13]>ClC1C=CC=CC=1>[S:2]1[C:3]2[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=2[C:5](=[O:13])[NH:6]1

참가 물질

5

반응물 3

HCID 962WaterHCID 24648Sulfuryl chlorideHCID 1387812-(Methylthio)benzonitrile

생성물 1

HCID 175201,2-Benzisothiazol-3(2H)-one수율 95.9%

시약·촉매·용매 1

HCID 7964Chlorobenzene용매

실험 절차

To a 500 ml four-necked flask equipped with a stirrer, a thermometer, and a condenser, 29.8 g (0.2 mol) of 2-(methylthio)benzonitrile, 100 g of monochlorobenzene, and 4.32 g (0.24 mol) of water were added. To the flask, 29.7 g (0.22 mol) of sulfuryl chloride was added with stirring at a temperature of from 5° to 15° C., heated to a temperature of from 70° to 80° C., and allowed to react for 1 hour. After the completion of the reaction, the reaction mixture was cooled to room temperature to precipitate white crystals. The white crystals were washed with monochlorobenzene, and dried to give 29.0 g of 1,2-benzisothiazol-3-one (melting point: 157° to 158° C.). The yield of the product was 96% against the starting 2-(methylthio)benzonitrile.

후처리

  1. customTo a 500 ml four-necked flask equipped with a stirrer
  2. temperatureheated to a temperature of from 70° to 80° C.
  3. customto react for 1 hour
  4. customAfter the completion of the reaction
  5. customto precipitate white crystals
  6. washThe white crystals were washed with monochlorobenzene
  7. customdried

출처 및 근거

ORD 기록
ord-ec3883f08a9549f0b176e5b6eb825c8b
출처 데이터셋
uspto-grants-1997_05
특허 번호
US05633384

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