Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → L-homoalanin-4-yl(methyl)phosphinic acid hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | (4S)-3-benzyloxycarbonyl-4-{2-[ethoxy(methyl)phosphinyl]ethyl}-1,3-oxazolidin-5-one | HCID 14596286 | — |
| 생성물 | L-homoalanin-4-yl(methyl)phosphinic acid hydrochloride | HCID 12701464 | 82.1% |
반응 단계
0.50 g (1.4 mmol) of (4S)-3-benzyloxycarbonyl-4-{2-[ethoxy (methyl)phosphinyl]ethyl}-1,3-oxazolidin-5-one (from Example 12) are, as described in DE-A-3,817,956, hydrolyzed by heating in 6 N hydrochloric acid. 0.25 g (82.1% of theory) of L-homoalanin-4-yl(methyl)phosphinic acid hydrochloride are obtained as a white solid having a melting point of Mp 202° C. (decomposition).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05633385 |
| 출처 데이터셋 | uspto-grants-1997_05 |
| ORD ID | ord-5f2c33553b284f46a23392b59f9c40f9 |
| 출처 메모 | uspto-grants-1997_05 |