Ethanol → 2-Fluoro-3,4-dihydroxy-5-nitrobenzonitrile

HRID 1781854노트

반응식

HRID 1781854 반응식
[F:1][C:2]1[C:9]([OH:10])=[C:8]([O:11]C)[C:7]([N+:13]([O-:15])=[O:14])=[CH:6][C:3]=1[C:4]#[N:5].B(Br)(Br)Br.C(O)C>C(Cl)Cl>[F:1][C:2]1[C:9]([OH:10])=[C:8]([OH:11])[C:7]([N+:13]([O-:15])=[O:14])=[CH:6][C:3]=1[C:4]#[N:5]

참가 물질

5

반응물 3

HCID 702EthanolHCID 25134Boron tribromide2회HCID 214591212-Fluoro-3-hydroxy-5-nitro-p-anisonitrile

생성물 1

HCID 214589472-Fluoro-3,4-dihydroxy-5-nitrobenzonitrile

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

550 mg of 2-fluoro-3-hydroxy-5-nitro-p-anisonitrile are dissolved in 30 ml of methylene chloride, whereupon the solution is treated with 0.44 ml of boron tribromide. After stirring at 23° for 6 hours an additional 0.1 ml of boron tribromide are added thereto, whereupon the mixture is stirred at 23° for an additional 1.5 hours. Thereupon, 3 ml of ethanol are added thereto at -15°. The reaction mixture is evaporated and the residue is dried in a high vacuum at 23°. By recrystallization from ether/hexane there is obtained 2-fluoro-3,4-dihydroxy-5-nitrobenzonitrile of m.p. 154°.

후처리

  1. additionare added
  2. customat -15°
  3. customThe reaction mixture is evaporated
  4. customthe residue is dried in a high vacuum at 23°
  5. customBy recrystallization from ether/hexane there

출처 및 근거

ORD 기록
ord-abef29f5caa94a9cb778712b3fff66cd
출처 데이터셋
uspto-grants-1997_05
특허 번호
US05633371

반응 노트

불러오는 중…