Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cesium carbonate → HCID 86612855, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | Benzenesulfonic acid, 3-nitro-, (2S)-2-oxiranylmethyl ester | HCID 146490 | — |
| 반응물 | 2-(2-hydroxy-4-methoxyphenyl)-N-methylacetamide | HCID 69017352 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 86612855 | HCID 86612855 | 94.3% |
반응 단계
A mixture of 2-(2-hydroxy-4-methoxyphenyl)-N-methylacetamide (15 mg, 0.076 mmol), (2S)-oxiran-2-ylmethyl 3-nitrobenzenesulfonate (20 mg, 0.076 mmol) and Cs2CO3 (30 mg, 0.091 mmol) in DMF (1.5 mL) was stirred at room temperature overnight. The reaction mixture was partitioned between ethyl acetate and H2O. The organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel flash chromatography (0-100% ethyl acetate in petroleum spirit) to give the subtitled compound (18 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07498338B2 |
| 출처 데이터셋 | uspto-grants-2009_03 |
| ORD ID | ord-bdf2fce010bd419281858860233fc2c2 |
| 출처 메모 | uspto-grants-2009_03 |