1,3-Dichloro-2-isocyanatobenzene → 1-(2,6-Dichlorophenyl)3-(thieno[3,2-d]pyrimidin-4-yl)urea

HRID 1782069

반응식

HRID 1782069 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]=[C:10]=[O:11].[NH2:12][C:13]1[C:14]2[S:21][CH:20]=[CH:19][C:15]=2[N:16]=[CH:17][N:18]=1>C(#N)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]([NH:12][C:13]1[C:14]2[S:21][CH:20]=[CH:19][C:15]=2[N:16]=[CH:17][N:18]=1)=[O:11]

참가 물질

4

반응물 2

HCID 6045371,3-Dichloro-2-isocyanatobenzeneHCID 11506485Thieno(3,2-d)pyrimidin-4-amine

생성물 1

HCID 99239551-(2,6-Dichlorophenyl)3-(thieno[3,2-d]pyrimidin-4-yl)urea수율 229.1%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

2,6-Dichlorophenyl isocyanate (0.075 g) was added to a mixture of 4-aminothieno[3,2-d]pyrimidine (Tetrahedron, 1971, 27, 487; 0.201 g) and acetonitrile (16 ml) and the resultant mixture was stirred at ambient temperature for 16 hours. The precipitate was isolated and washed in turn with diethyl ether and methanol. There was thus obtained the title compound (0.31 g); NMR Spectrum: (DMSOd6) 7.25 (t, 1H), 7.45 (d, 1H), 7.55 (d, 1H), 7.95 (d, 1H), 8.4 (s, 1H), 8.8 (s, 1H), 11.7 (br s, 1H); Mass Spectrum: M+H+ 339 and 341; Elemental Analysis: Found C, 45.8; H 2.4; N, 16.5; C13H8Cl2N4OS requires C, 46.03; H, 2.38; N, 16.52%.

후처리

  1. customThe precipitate was isolated
  2. washwashed in turn with diethyl ether and methanol

출처 및 근거

ORD 기록
ord-8db3ef97975143c1821bcb5b829ec461
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07498335B2

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