Ammonia → (Dimethyl-1,2-oxazol-4-yl)methanamine

HRID 1783268

반응식

HRID 1783268 반응식
Cl[CH2:2][C:3]1[C:4]([CH3:9])=[N:5][O:6][C:7]=1[CH3:8].[NH3:10]>>[NH2:10][CH2:2][C:3]1[C:4]([CH3:9])=[N:5][O:6][C:7]=1[CH3:8]

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 88246Isoxazole, 4-(chloromethyl)-3,5-dimethyl-

생성물 1

HCID 11018874(Dimethyl-1,2-oxazol-4-yl)methanamine

실험 절차

4-Chloromethyl-3,5-dimethylisoxazole (700 mg, 4.8 mmol) is suspended in concentrated aqueous ammonia at 20-25 degrees C., and vigorously stirred overnight. The reaction mixture is extracted with isopropyl alcohol/chloroform (10/90, 2×). The combined organic phases are concentrated under nitrogen flow. The residue is purified by flash chromatography methanol/methylene chloride (5-20%, 1% triethylamine) to give the title compound, MR (CDCl3, 300 MHz) delta 3.62, 2.37, 2.29, and 1.44.

후처리

  1. customvigorously stirred overnight
  2. extractionThe reaction mixture is extracted with isopropyl alcohol/chloroform (10/90, 2×)
  3. concentrationThe combined organic phases are concentrated under nitrogen flow
  4. customThe residue is purified by flash chromatography methanol/methylene chloride (5-20%, 1% triethylamine)

출처 및 근거

ORD 기록
ord-baadfe228970474f9ccf855c160cc0da
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07498436B2

연결된 노트

불러오는 중…