Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetonitrile → 2-[4-(4-tert-Butylbenzyl)piperazin-1-yl]-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 1-Cinnamylpiperazine | HCID 726896 | — |
| 반응물 | 2-bromo-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide | HCID 22379151 | — |
| 생성물 | 2-[4-(4-tert-Butylbenzyl)piperazin-1-yl]-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide | HCID 22378962 | — |
반응 단계
To a stirred solution of 2-bromo-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide (0.80 g in 40 ml acetonitrile) was added [(2E)-3-phenylprop-2-enyl]piperazine (0.50 g in 10 ml acetonitrile). After 3 hrs, N,N-diisopropylethylamine was added (428 μl in 10 ml acetonitrile) and the reaction stirred for a further 2 hrs after which time a precipitate of the title compound appeared. This was used crude in the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07501407B2 |
| 출처 데이터셋 | uspto-grants-2009_03 |
| ORD ID | ord-672ef598fb674a0f9bd424ca5278f4f3 |
| 출처 메모 | uspto-grants-2009_03 |