4-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl ester → 4-Methyl-3-((4-(pyrazin-2-yl)pyrimidin-2-yl)amino)benzoic acid
반응식
C([O:3][C:4](=[O:25])[C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[C:7]([NH:12][C:13]2[N:18]=[C:17]([C:19]3[CH:24]=[N:23][CH:22]=[CH:21][N:20]=3)[CH:16]=[CH:15][N:14]=2)[CH:6]=1)C.C(OC(=O)C1C=CC(NC2N=C(C3C=NC=CC=3)C=CN=2)=CC=1)C>>[CH3:11][C:8]1[CH:9]=[CH:10][C:5]([C:4]([OH:25])=[O:3])=[CH:6][C:7]=1[NH:12][C:13]1[N:18]=[C:17]([C:19]2[CH:24]=[N:23][CH:22]=[CH:21][N:20]=2)[CH:16]=[CH:15][N:14]=1참가 물질
3
실험 절차
4-methyl-3-(4-pyrazin-2-yl-pyrimidin-2-ylamino)-benzoic acid ethyl ester prepared in Preparation 11 was used instead of 4-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl ester according to the similar procedure to Preparation 19 to give the titled compound as yellow solid.
출처 및 근거
- ORD 기록
- ord-24582fa9f41640f4aabdd175869c75e0
- 출처 데이터셋
- uspto-grants-2009_03
- 특허 번호
- US07501424B2
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