Trifluoroacetic acid → 2-Chloro-3,5-Dimethoxyaniline

HRID 1783548

반응식

HRID 1783548 반응식
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[C:10]([O:16][CH3:17])[C:9]=1[Cl:18])(C)(C)C.FC(F)(F)C(O)=O>>[Cl:18][C:9]1[C:10]([O:16][CH3:17])=[CH:11][C:12]([O:14][CH3:15])=[CH:13][C:8]=1[NH2:7]

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 54265450HCID 54265450, 화합물

생성물 1

HCID 227430742-Chloro-3,5-Dimethoxyaniline수율 101,012.797%

실험 절차

To 6.01 g (0.021 mmol) of (2-chloro-3,5-dimethoxy-phenyl)-carbamic acid tert-butyl ester was added 15 mL of trifluoroacetic acid. The reaction was stirred for 3 hours at room temperature, then concentrated in vacuo. The residue was made basic with a saturated solution of sodium bicarbonate, then extracted three times with dichloromethane. The combined dichloromethane layers were dried with magnesium sulfate and concentrated in vacuo to give 3.98 g of the title compound, which was used as is in the following example.

후처리

  1. concentrationconcentrated in vacuo
  2. extractionextracted three times with dichloromethane
  3. dry with materialThe combined dichloromethane layers were dried with magnesium sulfate
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-c7d2e9ad817e419e9dccae79ac1fec04
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07501425B1

연결된 노트

불러오는 중…