Selenium Dioxide → Quinazoline-6-carbaldehyde
반응식
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[CH:5]2.[Se](=O)=[O:13]>CO>[N:8]1[C:9]2[C:4](=[CH:3][C:2]([CH:1]=[O:13])=[CH:11][CH:10]=2)[CH:5]=[N:6][CH:7]=1참가 물질
4
반응 조건
- 온도
- 160 °C
실험 절차
The mixture of 6-methyl-quinazoline (5.0 g, 34.7 mmol) and selenium dioxide (7.7 g, 69.4 mmol) was heated at 160° C. for 12 hours. After cooling to room temperature, methanol was added with stirring. After removal of solid by filtration, the filtrate was concentrated. Flash chromatography (Merck Silica gel 60, 230-400 mesh, 0%-30% ethyl acetate in hexane in 30 min) afforded 6-quinazolinecarboxaldehyde (2.4 g, 43.7%) as a white solid: LC-MS m/e 159 (MH+).
후처리
- temperatureAfter cooling to room temperature
- customAfter removal of solid
- filtrationby filtration
- concentrationthe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-4932d407f85c4531818eec34895cacb4
- 출처 데이터셋
- uspto-grants-2009_03
- 특허 번호
- US07501428B2
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