Potassium Carbonate → HCID 16788087, 화합물

HRID 1783751노트

반응식

HRID 1783751 반응식
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[N:11]1(C(O)=O)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.[C:20]([O-])([O-:22])=[O:21].[K+].[K+].CN1C(=O)CCC1>O>[N+:8]([C:7]1[C:2]([N:11]2[CH2:12][CH2:13][CH:14]([C:20]([OH:22])=[O:21])[CH2:15][CH2:16]2)=[N:3][CH:4]=[CH:5][CH:6]=1)([O-:10])=[O:9]

참가 물질

6

반응물 4

HCID 11430Potassium CarbonateHCID 13387N-methyl-2-pyrrolidoneHCID 796132-Chloro-3-nitropyridineHCID 9964094Piperidine-1-carboxylic acid

생성물 1

HCID 16788087HCID 16788087, 화합물

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
80 °C

실험 절차

The mixture consisting of 634 mg of 2-chloro-3-nitropyridine, 620 mg of piperidine carboxylic acid, 820 mg of potash and 3 ml of NMP was stirred at 80° C. for 2 hours. After allowing to cool, 30 ml of water of water were added and the crude product was extracted with 30 ml of ethyl acetate. After drying the organic phase with sodium sulfate, it was concentrated under reduced pressure.

후처리

  1. temperatureto cool
  2. extractionthe crude product was extracted with 30 ml of ethyl acetate
  3. dry with materialAfter drying the organic phase with sodium sulfate, it
  4. concentrationwas concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-167c65b36ef045c2878dd95c113c12bc
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07501440B2

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