2-Chloro-5-nitrobenzenesulfonamide → 2-Cyclopropylamino-5-nitrobenzenesulphonamide

HRID 17838

반응식

HRID 17838 반응식
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[S:11]([NH2:14])(=[O:13])=[O:12].[CH:15]1([NH2:18])[CH2:17][CH2:16]1>O1CCOCC1>[CH:15]1([NH:18][C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=2[S:11]([NH2:14])(=[O:13])=[O:12])[CH2:17][CH2:16]1

참가 물질

4

반응물 2

HCID 667842-Chloro-5-nitrobenzenesulfonamideHCID 69828Cyclopropylamine

생성물 1

HCID 675301582-Cyclopropylamino-5-nitrobenzenesulphonamide

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

2-Chloro-5-nitrobenzenesulphonamide (5 g) prepared in the Step above is introduced into a hermetically closed vessel containing a mixture of dioxane (70 mL) and cyclopropylamine (3.5 mL). The hermetically closed vessel is placed in an oven at 100° C. for 24 hours. After this time period, the solvent and the reagent are removed by concentrating under reduced pressure. The residue is taken up in methanol (20 mL) and the insoluble material, which contains the title product, is collected by filtration, washed with methanol and dried.

후처리

  1. additionabove is introduced into a hermetically closed vessel
  2. additioncontaining
  3. customAfter this time period, the solvent and the reagent are removed
  4. concentrationby concentrating under reduced pressure
  5. filtrationis collected by filtration
  6. washwashed with methanol
  7. customdried

출처 및 근거

ORD 기록
ord-cc7cdf4d90fc4c72980716ddfe9808c6
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741320B2

연결된 노트

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