Methylamine → 4-Bromo-N-methylthiazole-2-carboxamide

HRID 1783964노트

반응식

HRID 1783964 반응식
C([O:3][C:4]([C:6]1[S:7][CH:8]=[C:9]([Br:11])[N:10]=1)=O)C.[CH3:12][NH2:13]>CO>[CH3:12][NH:13][C:4]([C:6]1[S:7][CH:8]=[C:9]([Br:11])[N:10]=1)=[O:3]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 49757955Ethyl 4-bromothiazole-2-carboxylate

생성물 1

HCID 575900864-Bromo-N-methylthiazole-2-carboxamide

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

4-Bromothiazole-2-carboxylic acid ethyl ester (500 mg, 2.13 mmol) is dissolved in methanol (1 mL) and methyl amine in methanol (10 mL) is added. The mixture is stirred overnight at room temperature. Evaporation of the solvent under reduced pressure affords the title compound as yellow solid. LCMS: Rt 0.92 min (100%) m/z (ESI) 219/221 (M+H)+.

후처리

  1. customEvaporation of the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-d3bbd687e934429f83c1107e159f79da
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07501411B2

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