4-Chloroaniline → AF-794/00086051

HRID 1784041노트

반응식

HRID 1784041 반응식
[C:1]1(=[O:7])[O:6][C:4](=[O:5])[CH:3]=[CH:2]1.[Cl:8][C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[CH:11][CH:10]=1>C(#N)C>[Cl:8][C:9]1[CH:15]=[CH:14][C:12]([NH:13][C:1](/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5])=[O:7])=[CH:11][CH:10]=1

참가 물질

4

반응물 2

HCID 78124-ChloroanilineHCID 7923Maleic Anhydride

생성물 1

HCID 5356193AF-794/00086051수율 97.1%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of 29.3 g (300 mmol) of maleic anhydride in 500 ml of acetonitrile was treated portionwise with 40 g (310 mmol) of 4-chloroaniline and stirred at room temperature during 24 hrs. The thick precipitate that had formed was filtered off, washed with cold acetonitrile and dried i.v. to yield 65.7 g (97%)of the title compound. Yellow solid. MS: 226 (M+H)+.

후처리

  1. customThe thick precipitate that had formed
  2. filtrationwas filtered off
  3. washwashed with cold acetonitrile
  4. customdried i.v

출처 및 근거

ORD 기록
ord-ebd3d6c044f84cc9a66afcd766b68400
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07501413B2

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