Potassium Carbonate → 3-(4-Bromophenyl)piperidin-2-one
반응식
Cl.C(OC(=O)[CH2:6][CH:7]([C:12]1[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][CH:13]=1)[CH2:8][CH2:9][CH2:10][NH2:11])C.C(=O)([O-])[O-:21].[K+].[K+]>C(O)C>[Br:18][C:15]1[CH:16]=[CH:17][C:12]([CH:7]2[CH2:8][CH2:9][CH2:10][NH:11][C:6]2=[O:21])=[CH:13][CH:14]=1참가 물질
4
실험 절차
A solution of 6-amino-3-(4-bromo-phenyl)-hexanoic acid ethyl ester hydrochloride, potassium carbonate (1039 mg, 7.52 mmol) in ethanol (50 ml) was refluxed for 20 hr. Solvent was removed in vacuo after addition of dilute hydrochloric acid and water was added to the residue. Filtration, wash with water and dryness afforded 3-(4-Bromo-phenyl)-piperidin-2-one (1387 mg, 86%, 2 steps).
후처리
- customSolvent was removed in vacuo
- additionafter addition of dilute hydrochloric acid and water
- additionwas added to the residue
- filtrationFiltration
- washwash with water and dryness
출처 및 근거
- ORD 기록
- ord-a1fbf437c99243d6ad6d224e40c0c375
- 출처 데이터셋
- uspto-grants-2009_03
- 특허 번호
- US07504411B2
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