2-Amino-5-nitropyridine → 3-Methyl-6-nitroimidazo[1,2-a]pyridine

HRID 1784727노트

반응식

HRID 1784727 반응식
Br[CH:2]([CH3:5])[CH:3]=O.[NH2:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][N:8]=1>C(OCC)(=O)C>[CH3:5][C:2]1[N:8]2[CH:9]=[C:10]([N+:13]([O-:15])=[O:14])[CH:11]=[CH:12][C:7]2=[N:6][CH:3]=1

참가 물질

4

반응물 2

HCID 778882-Amino-5-nitropyridineHCID 3506242-Bromopropanal

생성물 1

HCID 218273463-Methyl-6-nitroimidazo[1,2-a]pyridine

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Operations similar to Production Example 1-(2) were conducted using 2-bromopropionaldehyde and 2-amino-5-nitropyridine. The solid whereupon obtained was suspended in ethyl acetate, and washed with saturated aqueous sodium hydrogencarbonate solution to provide the title compound as yellow solid.

후처리

  1. customThe solid whereupon obtained
  2. washwashed with saturated aqueous sodium hydrogencarbonate solution

출처 및 근거

ORD 기록
ord-08e9c128559343a49cfbb57ed99de03f
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07504412B2

반응 노트

불러오는 중…