4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid → Methyl 3-methyl-6-({[4'-(trifluoromethyl) [1,1'-biphenyl]-4-yl]-carbonyl}amino)-imidazo[1,2-a]pyridine-2-carboxylate
반응식
[CH3:1][C:2]1[N:6]2[CH:7]=[C:8]([N+:11]([O-])=O)[CH:9]=[CH:10][C:5]2=[N:4][C:3]=1[C:14]([O:16][CH3:17])=[O:15].[F:18][C:19]([F:36])([F:35])[C:20]1[CH:25]=[CH:24][C:23]([C:26]2[CH:31]=[CH:30][C:29]([C:32](O)=[O:33])=[CH:28][CH:27]=2)=[CH:22][CH:21]=1>>[CH3:1][C:2]1[N:6]2[CH:7]=[C:8]([NH:11][C:32]([C:29]3[CH:28]=[CH:27][C:26]([C:23]4[CH:24]=[CH:25][C:20]([C:19]([F:18])([F:35])[F:36])=[CH:21][CH:22]=4)=[CH:31][CH:30]=3)=[O:33])[CH:9]=[CH:10][C:5]2=[N:4][C:3]=1[C:14]([O:16][CH3:17])=[O:15]참가 물질
3
실험 절차
Operations similar to those of Example 1 were conducted using methyl 3-methyl-6-nitroimidazo[1,2-a]pyridine-2-carboxylate and 4′-(trifluoromethyl)[1,1′-biphenyl]-4-carboxylic acid, to provide methyl 3-methyl-6-({[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]-carbonyl}amino)-imidazo[1,2-a]pyridine-2-carboxylate as white solid.
출처 및 근거
- ORD 기록
- ord-35e34d64bc5c4d9e8fe81e0963413302